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- Title
DIALIGN: finding local similarities by multiple sequence alignment.
- Authors
Morgenstern, B; Frech, K; Dress, A; Werner, T
- Abstract
DIALIGN is a new method for pairwise as well as multiple alignment of nucleic acid and protein sequences. While standard alignment programs rely on comparing single residues and imposing gap penalties, DIALIGN constructs alignments by comparing whole segments of the sequences. No gap penalty is employed. This point of view is especially adequate if sequences are not globally related, but share only local similarities, as is the case in genomic DNA sequences and in many protein families.
- Publication
Bioinformatics (Oxford, England), 1998, Vol 14, Issue 3, p290
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/14.3.290