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- Title
Flux balance analysis in the era of metabolomics.
- Authors
Jong Min Lee; Gianchandani, Erwin P.; Papin, Jason A.
- Abstract
Flux balance analysis (FBA) has emerged as an effective means to analyse biological networks in a quantitative manner. Much progress has been made on the extension of FBA to incorporate a priori biological knowledge, provide more practical descriptions of observed cell behaviours, and predict the outcome of network perturbations Metabolomics is independently advancing as a set of high-throughput data acquisition tools providing dynamic profiles of metabolites in an unbiased manner. These data sets are neither yet sufficiently comprehensive nor accurate enough for generating large-scale kinetic models. Thus, there is a pressing need to develop that can make use of the emerging data and embrace the associated uncertainties. This article reviews recent advances in FBA to meet this need and disc- the utility of FBA as a complement to metabolomics and the expected synergy as a result of combining these two techniques.
- Publication
Briefings in Bioinformatics, 2006, Vol 7, Issue 2, p140
- ISSN
1467-5463
- Publication type
Academic Journal
- DOI
10.1093/bib/bbl007