Title

Clinical bioinformatics desiderata for molecular tumor boards.

Authors

Pallocca, Matteo; Betti, Martina; Baldinelli, Sara; Palombo, Ramona; Bucci, Gabriele; Mazzarella, Luca; Tonon, Giovanni; Ciliberto, Gennaro

Abstract

Clinical Bioinformatics is a knowledge framework required to interpret data of medical interest via computational methods. This area became of dramatic importance in precision oncology, fueled by cancer genomic profiling: most definitions of Molecular Tumor Boards require the presence of bioinformaticians. However, all available literature remained rather vague on what are the specific needs in terms of digital tools and expertise to tackle and interpret genomics data to assign novel targeted or biomarker-driven targeted therapies to cancer patients. To fill this gap, in this article, we present a catalog of software families and human skills required for the tumor board bioinformatician, with specific examples of real-world applications associated with each element presented.

Subjects

MEDICAL informatics; DIGITAL technology; CANCER patients; GENOMICS; CANCER treatment

Publication

Briefings in Bioinformatics, 2024, Vol 25, Issue 5, p1

ISSN

1467-5463

Publication type

Academic Journal

DOI

10.1093/bib/bbae447