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- Title
Exploring cell type-specific internalizing antibodies for targeted delivery of siRNA.
- Authors
Bin Liu
- Abstract
A major challenge to the development of therapeutic small interfering RNAs (siRNAs) is specific and efficient in vivo delivery to target cells. Recent studies suggest that cell type-specific gene silencing in vivo can be achieved by combining siRNAs with cell type-specific affinity ligands such as monoclonal antibodies. The antibody-directed siRNA complex enters target cells through receptor endocytosis and is subsequently released to the cytosol to specifically silence target gene expression through biologically conserved RNA interference (RNAi) pathways. Antibody fragments fused with a small basic nucleic-acid-binding protein and antibody fragment-directed nano-immunoliposomes are two examples of effective delivery vehicles in vivo. The demonstrated specificity of in vivo gene silencing and the lack of nonspecific immune activation and systemic toxicity encourage further development of therapies based on cell type-specific delivery of siRNA.
- Publication
Briefings in Functional Genomics & Proteomics, 2007, Vol 6, Issue 2, p112
- ISSN
1473-9550
- Publication type
Academic Journal
- DOI
10.1093/bfgp/elm015