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- Title
Overcoming resistance and restoring sensitivity to HER2-targeted therapies in breast cancer.
- Authors
Mohd Sharial, M S N; Crown, J; Hennessy, B T
- Abstract
Approximately 15%-23% of breast cancers overexpress human epidermal growth factor receptor 2 (HER2), which leads to the activation of signaling pathways that stimulate cell proliferation and survival. HER2-targeted therapy has substantially improved outcomes in patients with HER2-positive breast cancer. However, both de novo and acquired resistance are observed.
- Publication
Annals of oncology : official journal of the European Society for Medical Oncology, 2012, Vol 23, Issue 12, p3007
- ISSN
1569-8041
- Publication type
Journal Article
- DOI
10.1093/annonc/mds200