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- Title
Poor prognosis nonseminomatous germ-cell tumours (NSGCTs): should chemotherapy doses be reduced at first cycle to prevent acute respiratory distress syndrome in patients with multiple lung metastases?
- Authors
Massard, C; Plantade, A; Gross-Goupil, M; Loriot, Y; Besse, B; Raynard, B; Blot, F; Antoun, S; Nitenberg, G; Escudier, B; Fizazi, K
- Abstract
Patients with extensive lung metastases from nonseminomatous germ-cell tumours (NSGCTs) and dyspnoea at presentation are at high risk of acute respiratory distress syndrome (ARDS) and death within the first weeks after chemotherapy induction. This syndrome is linked to acute intra-alveolar haemorrhage related to early tumour necrosis, which in turn, can be complicated by pulmonary infection promoted by neutropenia. The management of these patients was modified at Institut Gustave Roussy in 1997 to try to avoid this complication.
- Publication
Annals of oncology : official journal of the European Society for Medical Oncology, 2010, Vol 21, Issue 8, p1585
- ISSN
1569-8041
- Publication type
Journal Article
- DOI
10.1093/annonc/mdq021