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- Title
Phase I clinical trial of i.v. ascorbic acid in advanced malignancy.
- Authors
Hoffer, L J; Levine, M; Assouline, S; Melnychuk, D; Padayatty, S J; Rosadiuk, K; Rousseau, C; Robitaille, L; Miller, W H, Jr
- Abstract
Ascorbic acid is a widely used and controversial alternative cancer treatment. In millimolar concentrations, it is selectively cytotoxic to many cancer cell lines and has in vivo anticancer activity when administered alone or together with other agents. We carried out a dose-finding phase I and pharmacokinetic study of i.v. ascorbic acid in patients with advanced malignancies.
- Publication
Annals of oncology : official journal of the European Society for Medical Oncology, 2008, Vol 19, Issue 11, p1969
- ISSN
1569-8041
- Publication type
Journal Article
- DOI
10.1093/annonc/mdn377