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- Title
The estrogen receptor alpha:insulin receptor substrate 1 complex in breast cancer: structure-function relationships.
- Authors
Sisci, D; Morelli, C; Cascio, S; Lanzino, M; Garofalo, C; Reiss, K; Garcia, M; Russo, A; Andò, S; Surmacz, E
- Abstract
Insulin receptor substrate 1 (IRS-1) is a signaling molecule that exerts a key role in mediating cross talk between estrogen receptor alpha (ERalpha) and insulin-like growth factor 1 (IGF-1) in breast cancer cells. Previously, we demonstrated that a fraction of IRS-1 binds ERalpha, translocates to the nucleus, and modulates ERalpha-dependent transcription at estrogen response elements (ERE). Here, we studied structure-function relationships of the ERalpha:IRS-1 complex under IGF-1 and/or estradiol (E2) stimulation.
- Publication
Annals of oncology : official journal of the European Society for Medical Oncology, 2007, Vol 18 Suppl 6, pvi81
- ISSN
0923-7534
- Publication type
Journal Article
- DOI
10.1093/annonc/mdm232