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- Title
Topoisomerase I, II alpha and II beta mRNA expression in peripheral blood mononuclear cells of patients with solid tumor: preliminary results.
- Authors
Cartei, G; Trestin, A; Colombrino, E; Nadai, M; Richter, S N; Barzon, L; Palù, G; Palumbo, M; Padua Pharmacology Oncology Group (PPOG)
- Abstract
The pyrimidine antimetabolite Gemcitabine (G) (2',2'-difluorodeoxycytidine) is used against several malignancies G exerts its antitumour effect mainly by incorporation of its triphosphate metabolite (dFdCTP) into DNA. Subsequently, DNA polymerase adds one additional deoxynucleotide and DNA synthesis is interrupted. The nuclear enzymes topoisomerase I and II (TPs) are critical for DNA function and cell survival; they control, maintain and modify DNA topology during both replication and translation of genetic materials. These enzymes induce cuts in one or both strands of DNA, allowing strands to pass through the nick and then rejoining the nicked strand of DNA. Anti-topoisomerase (TPs-inhibitors) drugs exist and are largely used in chemotherapy, however, most often blindly of the cancer TPs status.
- Publication
Annals of oncology : official journal of the European Society for Medical Oncology, 2006, Vol 17 Suppl 5, pv25
- ISSN
1569-8041
- Publication type
Journal Article
- DOI
10.1093/annonc/mdj945