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- Title
A randomised trial in malignant mesothelioma (M) of early (E) versus delayed (D) chemotherapy in symptomatically stable patients: the MED trial.
- Authors
O'Brien, M E R; Watkins, D; Ryan, C; Priest, K; Corbishley, C; Norton, A; Ashley, S; Rowell, N; Sayer, R
- Abstract
Prior phase II trials have demonstrated the therapeutic activity of cytotoxic chemotherapy in mesothelioma. Currently there are few randomised data assessing the role of chemotherapy versus best supportive care (BSC) in the management of patients with stable symptoms after control of any pleural effusion. A policy of observation is often adopted over initial use of chemotherapy. In this prospective randomised trial we assess the use of early versus delayed cytotoxic therapy. The study opened in 1998, and closed in view of a competing national study (MSO 1) in 2003.
- Publication
Annals of oncology : official journal of the European Society for Medical Oncology, 2006, Vol 17, Issue 2, p270
- ISSN
0923-7534
- Publication type
Journal Article
- DOI
10.1093/annonc/mdj073