We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Lack of correlation between immunohistochemical expression of E2F-1, thymidylate synthase expression and clinical response to 5-fluorouracil in advanced colorectal cancer.
- Authors
Belvedere, O; Puglisi, F; Di Loreto, C; Cataldi, P; Guglielmi, A; Aschele, C; Sobrero, A
- Abstract
The level of the enzyme thymidylate synthase (TS) is known to inversely correlate with the clinical activity of 5-fluorouracil (FU) in advanced colorectal cancer patients. Since the correlation is not very strong, we have retrospectively analyzed the expression of E2F-1 in tumor samples or metastases from 25 patients with advanced colorectal cancer, homogeneously treated with an FU-based regimen. E2F-1 is a transcription factor regulating the expression of TS along with other crucial DNA synthesis related enzymes.
- Publication
Annals of oncology : official journal of the European Society for Medical Oncology, 2004, Vol 15, Issue 1, p55
- ISSN
0923-7534
- Publication type
Journal Article
- DOI
10.1093/annonc/mdh018