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- Title
The Hsp90 chaperone complex as a novel target for cancer therapy.
- Authors
Goetz, M P; Toft, D O; Ames, M M; Erlichman, C
- Abstract
Heat shock protein 90 (Hsp90) is responsible for chaperoning proteins involved in cell signaling, proliferation and survival. 17-allylamino-17-demethoxygeldanamycin (17-AAG) is an anticancer agent currently in phase I trials in the USA and UK. It represents a class of drugs, the benzoquinone ansamycin antibiotics, capable of binding and disrupting the function of Hsp90, leading to the depletion of multiple oncogenic client proteins.
- Publication
Annals of oncology : official journal of the European Society for Medical Oncology, 2003, Vol 14, Issue 8, p1169
- ISSN
0923-7534
- Publication type
Journal Article
- DOI
10.1093/annonc/mdg316