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- Title
DNA methyltransferase inhibitors-state of the art.
- Authors
Goffin, J; Eisenhauer, E
- Abstract
DNA methylation is the addition of a methyl group to the 5 position of cytosine. It is an epigenetic process with several effects, including chromatin structure modulation, transcriptional repression and the suppression of transposable elements. In malignancy, methylation patterns change, resulting in global hypomethylation with regional hypermethylation. This can lead to genetic instability and the repression of tumor suppressor genes.
- Publication
Annals of oncology : official journal of the European Society for Medical Oncology, 2002, Vol 13, Issue 11, p1699
- ISSN
0923-7534
- Publication type
Journal Article
- DOI
10.1093/annonc/mdf314