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- Title
Chemokines, cytokines and their receptors in Hodgkin's lymphoma cell lines and tissues.
- Authors
Maggio, E; van den Berg, A; Diepstra, A; Kluiver, J; Visser, L; Poppema, S
- Abstract
Hodgkin's lymphoma (HL) is characterized by a minority of neoplastic cells, the so-called Reed-Sternberg (RS) cells, and an admixture of reactive cells including lymphocytes, plasma cells, eosinophils and histiocytes. Cytokines produced in HL, either by RS or infiltrating cells, might explain the presence and maintenance of an impaired immune response. Chemokines (cytokines with chemoattractant properties) produced by RS cells play a major role in leukocyte trafficking. These molecules with specific receptor affinities contribute, for example by attracting TH2-like T cells, to the maintenance of a favorable environment for survival of RS cells.
- Publication
Annals of oncology : official journal of the European Society for Medical Oncology, 2002, Vol 13 Suppl 1, p52
- ISSN
0923-7534
- Publication type
Journal Article
- DOI
10.1093/annonc/13.s1.52