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- Title
Sex differences in caffeine neurotoxicity following chronic ethanol exposure and withdrawal.
- Authors
Butler, Tracy R; Smith, Katherine J; Berry, Jennifer N; Sharrett-Field, Lynda J; Prendergast, Mark A
- Abstract
Caffeine is a central nervous system stimulant that produces its primary effects via antagonism of the A(1) and A(2A) adenosine receptor subtypes. Previous work demonstrated a sex difference in neurotoxicity produced by specific adenosine A(1) receptor antagonism during ethanol withdrawal (EWD) in vitro that was attributable to effects downstream of A(1) receptors at NMDA receptors. The current studies were designed to examine the effect of non-specific adenosine receptor antagonism with caffeine during ethanol withdrawal on hippocampal toxicity in cultures derived from male and female rats.
- Publication
Alcohol and alcoholism (Oxford, Oxfordshire), 2009, Vol 44, Issue 6, p567
- ISSN
1464-3502
- Publication type
Journal Article
- DOI
10.1093/alcalc/agp050