We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
ROSIGLITAZONE RELIEVES ACUTE ETHANOL-INDUCED HANGOVER IN SPRAGUE-DAWLEY RATS.
- Authors
Tae Woo Jung; Ji Young Lee; Wan Sub Shim; Eun Seok Kang; Soo Kyung Mm; Chul Woo Ahn; Hyun Chul Lee; Bong Soo Cha
- Abstract
Aims: To assess the efficacy of rosiglitazone in blocking ethanol-induced hangover in rats. Methods: Rats injected with ethanol (4 g/kg body weight) were subjected to social interaction tests. Levels of aldehyde dehydrogenase 2 (ALD2), involved in an anti-hangover mechanism, were measured by semi-quantitative RT-PCR and western blot analysis. Results: Rosiglitazone caused an upregulation of mitochondrial ALD2, thus significantly detoxifying acetaldehyde. Conclusions: Rosiglitazone alleviated the symptoms of ethanol-induced hangover by inducing ALD2 expression; this result was reconfirmed by eliminating the effect of rosiglitazone by injecting cyanamide, an ALD2 inhibitor.
- Publication
Alcohol & Alcoholism, 2006, Vol 41, Issue 3, p231
- ISSN
0735-0414
- Publication type
Academic Journal
- DOI
10.1093/alcalc/agl013