We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The role of polymorphisms of glutathione S-transferases GSTM1, M3, P1, T1 and A1 in susceptibility to alcoholic liver disease.
- Authors
Brind, A M; Hurlstone, A; Edrisinghe, D; Gilmore, I; Fisher, N; Pirmohamed, M; Fryer, A A
- Abstract
Oxidant stress is proposed to be an important pathogenic factor in liver damage related to alcohol. The glutathione S-transferases (GSTs) are a group of polymorphic enzymes that are important in protection against oxidant stress. As there is evidence for genetic susceptibility to alcohol-related liver disease we have compared the frequency of polymorphisms of GSTM1, M3, P1, T1 and A1 by polymerase chain reaction (PCR) on leucocyte DNA in patients from North Staffordshire, Birmingham and Liverpool with alcohol-related chronic liver disease heavy drinking and normal local controls.
- Publication
Alcohol and alcoholism (Oxford, Oxfordshire), 2004, Vol 39, Issue 6, p478
- ISSN
0735-0414
- Publication type
Journal Article
- DOI
10.1093/alcalc/agh105