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- Title
Baclofen efficacy in reducing alcohol craving and intake: a preliminary double-blind randomized controlled study.
- Authors
Addolorato, Giovanni; Caputo, Fabio; Capristo, Esmeralda; Domenicali, Marco; Bernardi, Mauro; Janiri, Luigi; Agabio, Roberta; Colombo, Giancarlo; Gessa, Gian Luigi; Gasbarrini, Giovanni
- Abstract
The gamma-aminobutyric acid (GABA(B)) receptor agonist, baclofen, has recently been shown to reduce alcohol intake in alcohol-preferring rats and alcohol consumption and craving for alcohol in an open study in humans. The present study was aimed at providing a first evaluation of the efficacy of baclofen in inducing and maintaining abstinence and reducing craving for alcohol in alcohol-dependent patients in a double-blind placebo-controlled design.
- Publication
Alcohol and alcoholism (Oxford, Oxfordshire), 2002, Vol 37, Issue 5, p504
- ISSN
0735-0414
- Publication type
Journal Article
- DOI
10.1093/alcalc/37.5.504