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- Title
Invited commentary: the action in the interaction and exposure modification.
- Authors
Christiani, David C
- Abstract
The study of disease variability in populations is a goal of modern epidemiology. Because most common diseases arise out of a combination of factors and events (exposures, heritability, comorbidities, and chance), developing simple models of characterizing joint events is a daunting task. Dr. Weinberg argues successfully in this issue of the Journal (Am J Epidemiol. 2012;175(7):602-605) that additive null models can capture pure forms of independent causal effects in studies of rare conditions. Moreover, the concept of exposure modification, which characterizes most gene-environment interactions reported to date, is introduced. More cross-talk between biologists and epidemiologists is needed to tackle key issues in chronic disease etiology, and the argument for the use of parsimonious joint models in epidemiology is convincing.
- Publication
American journal of epidemiology, 2012, Vol 175, Issue 7, p606
- ISSN
1476-6256
- Publication type
Journal Article
- DOI
10.1093/aje/kwr498