We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Erectile Function and Risk of Parkinsons Disease.
- Authors
Xiang Gao; Honglei Chen; Michael A. Schwarzschild; Dale B. Glasser; Giancarlo Logroscino; Eric B. Rimm; Alberto Ascherio
- Abstract
Erectile dysfunction is common among individuals with Parkinsons disease, but it is unknown whether it precedes the onset of the classic features of Parkinsons disease. To address this question, the authors examined whether erectile dysfunction was associated with Parkinsons disease risk in the Health Professionals Follow-up Study. Analyses included 32,616 men free of Parkinsons disease at baseline in 1986 who in 2000 completed a retrospective questionnaire with questions on erectile dysfunction in different time periods. Relative risks were computed using Cox proportional hazards models adjusting for age, smoking, caffeine intake, history of diabetes, and other covariates. Among men who reported their erectile function before 1986, 200 were diagnosed with Parkinsons disease during 1986–2002. Men with erectile dysfunction before 1986 were 3.8 times more likely to develop Parkinsons disease during the follow-up than were those with very good erectile function (relative risk = 3.8, 95% confidence interval: 2.4, 6.0; p p = 0.008) for participants with first onset of erectile dysfunction (before 1986) at 60 or more, 50–59, and less than 50 years of age, respectively, relative to those without erectile dysfunction. In conclusion, in this retrospective analysis in a large cohort of men, the authors observed that erectile dysfunction was associated with a higher risk of developing Parkinsons disease.
- Publication
American Journal of Epidemiology, 2007, Vol 166, Issue 12, p1446
- ISSN
0002-9262
- Publication type
Academic Journal
- DOI
10.1093/aje/kwm246