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- Title
Analyzing vitamin D in foods and supplements: methodologic challenges.
- Authors
Byrdwell, W Craig; Devries, Jon; Exler, Jacob; Harnly, James M; Holden, Joanne M; Holick, Michael F; Hollis, Bruce W; Horst, Ronald L; Lada, Mark; Lemar, Linda E; Patterson, Kristine Y; Philips, Katherine M; Tarrago-Trani, Maria T; Wolf, Wayne R
- Abstract
This report briefly reviews existing methods for analyzing the vitamin D content of fortified and unfortified foods. The existing chemical methods are similar; all are time consuming, require experienced technicians, and have only been validated for a few materials (eg, dairy products or animal feed materials). This report also describes the lack of standard reference materials with certified values for vitamin D that laboratories need to guarantee the accuracy of existing analytic methods. Recently, the US Department of Agriculture, as part of a project to update the vitamin D values in the National Nutrient Database of Standard Reference, established an analytic methods committee to compare several existing vitamin D methods and to characterize 5 control materials (skim milk, processed cheese, cereal, orange juice, and salmon). Initial relative SDs for the 5 materials ranged from 35% to 50%. Elimination of systematic biases related to the methods and the standards yielded much more satisfactory relative SDs of 7% to 12%. This research has shown that existing methods for analyzing the vitamin D content in foods can produce accurate results. A new, simpler, and faster method, however, would greatly benefit the field. To guarantee accuracy, we need certified reference materials for foods.
- Publication
The American journal of clinical nutrition, 2008, Vol 88, Issue 2, p554S
- ISSN
1938-3207
- Publication type
Journal Article
- DOI
10.1093/ajcn/88.2.554S