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- Title
A functional 19-base pair deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer in multivitamin users.
- Authors
Xu, Xinran; Gammon, Marilie D; Wetmur, James G; Rao, Manlong; Gaudet, Mia M; Teitelbaum, Susan L; Britton, Julie A; Neugut, Alfred I; Santella, Regina M; Chen, Jia
- Abstract
Dihydrofolate reductase (DHFR) converts dihydrofolate (DHF) into tetrahydrofolate (THF) and plays an essential role in cell metabolism and cellular growth. Folic acid from multivitamins needs to be reduced by DHFR before it participates in cellular reactions.
- Publication
The American journal of clinical nutrition, 2007, Vol 85, Issue 4, p1098
- ISSN
0002-9165
- Publication type
Journal Article
- DOI
10.1093/ajcn/85.4.1098