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- Title
Efficacy of nonpharmacologic interventions in adults with high-normal blood pressure: results from phase 1 of the Trials of Hypertension Prevention. Trials of Hypertension Prevention Collaborative Research Group.
- Authors
Whelton, P K; Kumanyika, S K; Cook, N R; Cutler, J A; Borhani, N O; Hennekens, C H; Kuller, L H; Langford, H; Jones, D W; Satterfield, S; Lasser, N L; Cohen, J D
- Abstract
Phase 1 of the Trials of Hypertension Prevention was conducted in 2182 adults, aged 35-54 y, with diastolic blood pressure of 80-89 mm Hg to test the feasibility and blood pressure-lowering effects of seven nonpharmacologic interventions (weight loss, sodium reduction, stress management, and supplementation with calcium, magnesium, potassium, and fish oil). At 6 and 18 mo, weight loss and sodium reduction were well-tolerated and produced significant declines in systolic and diastolic blood pressures (-2.9/-2.4 and -2.1/-1.2 mm Hg for weight loss and sodium reduction, respectively, at 18 mo). None of the other interventions lowered blood pressure significantly at either the 6- or 18-mo follow-up visits. These results suggest that both weight loss and sodium reduction provide an effective means to prevent hypertension. The long-term effects of both of these interventions are being tested in phase 2 of the trial.
- Publication
The American journal of clinical nutrition, 1997, Vol 65, Issue 2 Suppl, p652S
- ISSN
0002-9165
- Publication type
Journal Article
- DOI
10.1093/ajcn/65.2.652S