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- Title
Metabolic effects of a low-glycemic-index diet.
- Authors
Jenkins, D J; Wolever, T M; Collier, G R; Ocana, A; Rao, A V; Buckley, G; Lam, Y; Mayer, A; Thompson, L U
- Abstract
Six healthy male volunteers underwent 2-wk metabolically controlled high-glycemic-index (GI) and low-GI diets in random order. Over the low-GI diet significant reductions were seen in serum fructosamine (7.0 +/- 1.0%, p less than 0.01), 12-h blood glucose profile (37 +/- 7%, p less than 0.01), and total serum cholesterol (15 +/- 3%, p less than 0.01). As a measure of insulin secretion, 24-h urinary C-peptide levels were 32 +/- 10% lower (p less than 0.05) after the low-GI than after the high-GI diet. Lower C-peptide levels were maintained after a standard carbohydrate challenge after the low-GI diet despite higher blood glucose levels. Differences in blood glucose were not seen after a 5-g intravenous glucose challenge. These results are of interest with respect to the effect that prolonged postprandial reductions in nutrient fluxes and insulin secretion may have on carbohydrate and lipid metabolism and renal function.
- Publication
The American journal of clinical nutrition, 1987, Vol 46, Issue 6, p968
- ISSN
0002-9165
- Publication type
Journal Article
- DOI
10.1093/ajcn/46.6.968