We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hypogeusia and zinc depletion in chronic dialysis patients.
- Authors
Atkin-Thor, E; Goddard, B W; O'Nion, J; Stephen, R L; Kolff, W J
- Abstract
Dialysis patients generally have a poor appetite, do not enjoy eating, and complain of food, particularly protein, as being disagreeable. Twenty dialysis patients with the above symptoms were tested for taste acuity, serum zinc (Zn), Zn concentrations in hair samples (intracellular Zn), and daily caloric intake. A double-blind, cross-over study was instituted using a Zn supplement and a placebo. After supplementation with Zn, taste acuity markedly improved in 95% of patients and Zn concentrations in hair increased in 85% of patients. The patients' appetites were improved; the average caloric intake increased by 675 kcal/day, and intolerance to protein diminished. In addition 10 normal control subjects were studied pre- and post-Zn supplementation for fasting blood glucose, serum Zn levels, and hair Zn concentration. Side effects were noted, and these usually correlated with elevated serum Zn levels and were minimized or disappeared with decrease in dosage or cessation of therapy.
- Publication
The American journal of clinical nutrition, 1978, Vol 31, Issue 10, p1948
- ISSN
0002-9165
- Publication type
Journal Article
- DOI
10.1093/ajcn/31.10.1948