We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Ghrelin fluctuation, what determines its production?
- Authors
Yin, Xuefeng; Li, Yin; Xu, Geyang; An, Wenjiao; Zhang, Weizhen
- Abstract
Ghrelin, a 28 amino acid gut brain peptide, acts as an endogenous ligand for its receptor, the growth hormone secretagogue receptor, to exercise a variety of functions ranging from stimulation of growth hormone secretion, regulation of appetite and energy metabolism, and cell protection to modulation of inflammation. This review summarizes the advance in the regulation of ghrelin expression and secretion. We introduce the structure of ghrelin promoter, the processing and modification of ghrelin precursor, and the regulation mechanism in these processes. Then we discuss factors found to be important in the regulation of ghrelin production, including nutrients, hormones, and autonomic nervous system. Finally, we outline the alteration in the level of ghrelin in certain physiological and pathological status.
- Publication
Acta biochimica et biophysica Sinica, 2009, Vol 41, Issue 3, p188
- ISSN
1745-7270
- Publication type
Journal Article
- DOI
10.1093/abbs/gmp001