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- Title
Environmental perchlorate and thiocyanate exposures and infant serum thyroid function.
- Authors
Leung, Angela M; Braverman, Lewis E; He, Xuemei; Schuller, Kristin E; Roussilhes, Alexandra; Jahreis, Katherine A; Pearce, Elizabeth N
- Abstract
Breastfed infants rely on maternal iodine for thyroid hormone production required for neurodevelopment. Dietary iodine among women of childbearing age in the United States may be insufficient. Perchlorate (competitive inhibitor of the sodium/iodide symporter [NIS]) exposure is ubiquitous. Thiocyanate, from cigarettes and diet, is a weaker NIS inhibitor. Environmental perchlorate and thiocyanate exposures could decrease breast milk iodine by competitively inhibiting NIS in lactating breasts (thus impairing infants' iodine availability), and/or infants' thyroidal NIS to directly decrease infant thyroid function. The current study assessed the relationships between environmental perchlorate and thiocyanate exposures and infant serum thyroid function.
- Publication
Thyroid : official journal of the American Thyroid Association, 2012, Vol 22, Issue 9, p938
- ISSN
1557-9077
- Publication type
Journal Article
- DOI
10.1089/thy.2012.0058