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- Title
Micro-single-photon emission computed tomography image acquisition and quantification of sodium-iodide symporter-mediated radionuclide accumulation in mouse thyroid and salivary glands.
- Authors
Brandt, Michael P; Kloos, Richard T; Shen, Daniel H; Zhang, Xiaoli; Liu, Yu-Yu; Jhiang, Sissy M
- Abstract
Micro-single-photon emission computed tomography (SPECT) provides a noninvasive way to evaluate the effects of genetic and/or pharmacological modulation on sodium-iodide symporter (NIS)-mediated radionuclide accumulation in mouse thyroid and salivary glands. However, parameters affecting image acquisition and analysis of mouse thyroids and salivary glands have not been thoroughly investigated. In this study, we investigated the effects of region-of-interest (ROI) selection, collimation, scan time, and imaging orbit on image acquisition and quantification of thyroidal and salivary radionuclide accumulation in mice.
- Publication
Thyroid : official journal of the American Thyroid Association, 2012, Vol 22, Issue 6, p617
- ISSN
1557-9077
- Publication type
Journal Article
- DOI
10.1089/thy.2011.0348