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- Title
A novel nitric oxide releasing prostaglandin analog, NCX 125, reduces intraocular pressure in rabbit, dog, and primate models of glaucoma.
- Authors
Borghi, Valentina; Bastia, Elena; Guzzetta, Massimiliano; Chiroli, Valerio; Toris, Carol B; Batugo, Minerva R; Carreiro, Samantha T; Chong, Wesley K M; Gale, David C; Kucera, David J; Jia, Liu; Prasanna, Ganesh; Ongini, Ennio; Krauss, Achim H P; Impagnatiello, Francesco
- Abstract
Nitric oxide (NO) is involved in a variety of physiological processes including ocular aqueous humor dynamics by targeting mechanisms that are complementary to those of prostaglandins. Here, we have characterized a newly synthesized compound, NCX 125, comprising latanoprost acid and NO-donating moieties.
- Publication
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2010, Vol 26, Issue 2, p125
- ISSN
1557-7732
- Publication type
Journal Article
- DOI
10.1089/jop.2009.0120