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- Title
Potential Benefit of Intraocular Pressure Reduction in Normal-Tension Glaucoma in South Korea.
- Authors
Je Seong, Gong; Rho, Sae Heun; Sik Kim, Chang; Moon, Jong Il; Kook, Michael Scott; Kim, Yong Yeon; Tak Ma, Kyoung; Jae Hong, Young; Nelson, Lindsay A.; Kruft, Bonnie; Stewart, Jeanette A.; Stewart, William C.
- Abstract
Purpose: The aim of this study was to evaluate the potential benefit of intraocular pressure (IOP) reduction in normaltension glaucoma (NTG) Asian adult patients in South Korea. Methods: This was a retrospective, multicenter analysis of 166 NTG Asian adult patients in South Korea. The patient population consisted of Korean patients with NTG with at least 5 years of records available for evaluation. Patients all had typical glaucomatous optic-disc and/or visual-field changes but had never had a recorded IOP >21 mmHg. Results: Overall, 48 (29%) patients were progressed and 116 (71%) were stable over the follow-up period. Of patients with IOPs ≤14mmHg (21/93), 23% progressed and ≥15mmHg (27/73) 37% progressed ( P = 0.041). The mean IOP for the stable group was 14.0 ± 1.8 mmHg, whereas with the progressed group the average mean IOP was 14.4 ± 1.6 mmHg ( P = 0.20). The mean peak IOP was 17.4 ± 2.2 mmHg in the stable group and 17.8 ± 2.0 mmHg in the progressed group ( P = 0.26). Multivariate linear regression analysis did not any identify independent risk factors for progression, including age, gender, or mean and peak IOP. Conclusions: This study provides initial evidence that Korean patients with normal-tension glaucoma, treated to lower IOPs, may have a decreased incidence of progression over 5 years than those patients with higher IOPs. More research is required to confirm this finding.
- Publication
Journal of Ocular Pharmacology & Therapeutics, 2009, Vol 25, Issue 1, p91
- ISSN
1080-7683
- Publication type
Academic Journal
- DOI
10.1089/jop.2008.0056