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- Title
-of-1 Randomized Controlled Trials: An Opportunity for Complementary and Alternative Medicine Evaluation.
- Authors
Johnston, Bradley C.; Mills, Edward
- Abstract
Complementary and alternative medicine (CAM) practice has traditionally relied on expert opinion and caseexamples to evaluate the outcome of a particular therapeutic treatment. Such trials are subject to bias, leadingto the formation of erroneous conclusions about the effectiveness of most treatments. This paper reviews thefeasibility of-of-1 trials to better evaluate the clinical and statistical significance of CAM therapies. In particular: (1) problems arising from the use of standard therapeutic trials; (2) the-of-1 trial and data analysis; (3) clinical use and advantages of the-of-1 trial in conventional medicine; (4) potential clinical uses of the-of-1 trial in CAM; (5) preliminary guidelines for the use of the n-of-1 trial in CAM; (6) constraints on the use of the n-of-1 trial in CAM; and (7) ethical issues in the conduct of the-of-1 trial.
- Publication
Journal of Alternative & Complementary Medicine, 2004, Vol 10, Issue 6, p979
- ISSN
1075-5535
- Publication type
Academic Journal
- DOI
10.1089/acm.2004.10.979