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- Title
Artichoke Leaf Extract Reduces Symptoms of Irritable Bowel Syndrome and Improves Quality of Life in Otherwise Healthy Volunteers Suffering from Concomitant Dyspepsia: A Subset Analysis.
- Authors
Bundy, Rafe; Walker, Ann F.; Middleton, Richard W.; Marakis, Georgios; Booth, Jonathan C.L.
- Abstract
Objectives: Does artichoke leaf extract (ALE) ameliorate symptoms of Irritable bowel syndrome (IBS) in otherwise heal thy volunteers suffering concomitant dyspepsia? Methods: A subset analysis of a previous dose-ranging, open, postal study, in adults suffering dyspepsia. Two hundred and eight (208) adults were identified post hoc as suffering with lBS. lBS incidence, self-reported usual bowel pattern, and the Nepean Dyspepsia Index (NDI) were compared before and after a 2-month intervention period. Results: There was a significant fall in lBS incidence of 26.4% (p <0.001) after treatment. A significant shift in self-reported usual bowel pattern away from "alternating constipation/diarrhea" toward "normal" (p < 0.001) was observed. NDI total symptom score significantly decreased by 41% (p <0.001) after treatment. Similarly, there was a significant 20% improvement in the NDI total quality-of-life (QOL) score in the subset after treatment. Conclusion: This report supports previous findings that ALE ameliorates symptoms of IBS, plus improves health-related QOL.
- Publication
Journal of Alternative & Complementary Medicine, 2004, Vol 10, Issue 4, p667
- ISSN
1075-5535
- Publication type
Academic Journal
- DOI
10.1089/1075553041829370