We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Proteome-wide anti-hepatitis C virus (HCV) and anti-HIV antibody profiling for predicting and monitoring the response to HCV therapy in HIV-coinfected patients.
- Authors
Burbelo, Peter D; Kovacs, Joseph A; Ching, Kathryn H; Issa, Alexandra T; Iadarola, Michael J; Murphy, Alison A; Schlaak, Joerg F; Masur, Henry; Polis, Michael A; Kottilil, Shyam
- Abstract
We quantified antibody responses to the hepatitis C virus (HCV) proteome that are associated with sustained virologic response (SVR) in human immunodeficiency virus (HIV)/HCV-coinfected patients treated with pegylated interferon and ribavirin. Analysis of pre- and posttreatment samples revealed significant decreases in the combined anti-core, anti-E1, and anti-NS4 HCV antibody titers in those with SVRs but not in those who experienced relapse or who did not respond. Furthermore, anti-HIV p24 antibody titers inversely correlated with treatment response. These results suggest that profiling anti-HCV antibody is useful for monitoring HCV therapy, especially in discriminating between those who experience relapse and those who have SVRs at 48 weeks.
- Publication
The Journal of infectious diseases, 2010, Vol 202, Issue 6, p894
- ISSN
1537-6613
- Publication type
Journal Article
- DOI
10.1086/655780