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- Title
Magnitude and breadth of a nonprotective neutralizing antibody response in an efficacy trial of a candidate HIV-1 gp120 vaccine.
- Authors
Gilbert, Peter; Wang, Maggie; Wrin, Terri; Petropoulos, Chris; Gurwith, Marc; Sinangil, Faruk; D'Souza, Patricia; Rodriguez-Chavez, Isaac R; DeCamp, Allan; Giganti, Mike; Berman, Phillip W; Self, Steve G; Montefiori, David C
- Abstract
A candidate vaccine consisting of human immunodeficiency virus type 1 (HIV-1) subunit gp120 protein was found previously to be nonprotective in an efficacy trial (Vax004) despite strong antibody responses against the vaccine antigens. Here we assessed the magnitude and breadth of neutralizing antibody responses in Vax004.
- Publication
The Journal of infectious diseases, 2010, Vol 202, Issue 4, p595
- ISSN
1537-6613
- Publication type
Journal Article
- DOI
10.1086/654816