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- Title
The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors.
- Authors
Einav, Shirit; Sobol, Hadas D; Gehrig, Elizabeth; Glenn, Jeffrey S
- Abstract
We recently identified a compound, clemizole hydrochloride, that inhibits NS4B's RNA binding and hepatitis C virus (HCV) replication. Although significant, clemizole's antiviral effect is moderate (50% effective concentration of 8 microM against an HCV genotype 2a clone). We hypothesized that the combination of clemizole with other anti-HCV agents can increase the antiviral effect over that achieved with each drug alone and could also decrease the emergence of viral resistance.
- Publication
The Journal of infectious diseases, 2010, Vol 202, Issue 1, p65
- ISSN
1537-6613
- Publication type
Journal Article
- DOI
10.1086/653080