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- Title
Clinical Significance of Cloned Expansion and CD5 Down-Regulation in Epstein-Barr Virus (EBV)— Infected CD8<sup>+</sup> T Lymphocytes in EBV-Associated Hemophagocytic Lymphohistiocytosis.
- Authors
Toga, Akiko; Wada, Taizo; Sakakibara, Yasuhisa; Mase, Shintaro; Araki, Raita; Tone, Yumi; Toma, Tomoko; Kurokawa, Toshiro; Yanagisawa, Ryu; Tamura, Kentaro; Nishida, Naonori; Taneichi, Hiromichi; Kanegane, Hirokazu; Yachie, Akihiro
- Abstract
Epstein-Barr virus (EBV) is the pathogen that most commonly triggers infection-associated hemophagocytic lymphohistiocytosis (HLH) and ectopically infects CD8+ T cells in EBV-associatedHLH (EBV-HLH). We recently described an EBV-HLH patient who had a clonally expanded population of EBV-infected CD8+ T cells with CD5 down-regulation. To determine whether this finding could serve as a useful marker for EBV-HLH, we investigated 5 additional patients. We found a significant increase in the subpopulation of CD8+ T cells with CD5 down-regulation and bright human leukocyte antigen (HLA)-DR expression in all patients with EBVHLH but not in patients with infectious mononucleosis or in control subjects. Such T cells were frequently found to be larger cells that stained positive for a specific T cell receptor VB. We also demonstrated that those cells were the major cellular target of EBV, and their numbers progressively declined in parallel with the serum ferritin levels. All together, our findings reveal the immunophenotypic characteristics of EBV-infected CD8+ T cells and may provide a valuable tool for the diagnosis of EBV-HLH.
- Publication
Journal of Infectious Diseases, 2010, Vol 201, Issue 12, p1923
- ISSN
0022-1899
- Publication type
Academic Journal
- DOI
10.1086/652752