We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Safety and cross-reactive immunogenicity of candidate AS03-adjuvanted prepandemic H5N1 influenza vaccines: a randomized controlled phase 1/2 trial in adults.
- Authors
Langley, Joanne M; Frenette, Louise; Ferguson, Linda; Riff, Dennis; Sheldon, Eric; Risi, George; Johnson, Casey; Li, Ping; Kenney, Richard; Innis, Bruce; Fries, Louis
- Abstract
The tocopherol-based oil-in-water emulsion adjuvant system family (AS03) improves antigen sparing with split-virion H5N1 influenza vaccines, representing an important development for pandemic preparedness. In this phase 1/2 randomized, controlled, observer-blinded study in 680 adults, we assessed the immunogenicity and safety of A/Indonesia/5/05 H5N1 (IBCDC-RG2, clade 2.1) prepandemic candidate vaccines produced at 2 separate manufacturing sites.
- Publication
The Journal of infectious diseases, 2010, Vol 201, Issue 11, p1644
- ISSN
1537-6613
- Publication type
Journal Article
- DOI
10.1086/652701