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- Title
Male circumcision decreases acquisition and increases clearance of high-risk human papillomavirus in HIV-negative men: a randomized trial in Rakai, Uganda.
- Authors
Gray, Ronald H; Serwadda, David; Kong, Xiangrong; Makumbi, Frederick; Kigozi, Godfrey; Gravitt, Patti E; Watya, Stephen; Nalugoda, Fred; Ssempijja, Victor; Tobian, Aaron A R; Kiwanuka, Noah; Moulton, Lawrence H; Sewankambo, Nelson K; Reynolds, Steven J; Quinn, Thomas C; Iga, Boaz; Laeyendecker, Oliver; Oliver, Amy E; Wawer, Maria J
- Abstract
Uncircumcised human immunodeficiency virus (HIV)-negative men aged 15-49 years were randomized to immediate circumcision (intervention arm, 441 subjects) or delayed circumcision (control arm, 399 subjects). Human papillomavirus (HPV) was detected by Roche HPV Linear Array at enrollment, and at 6, 12, and 24 months. Incident high-risk HPV (HR-HPV) was estimated in men who acquired a new HR-HPV genotype. HR-HPV clearance was determined in men with prior genotype-specific HR-HPV infections. Rate ratios (RRs) and 95% confidence intervals (CIs) of HR-HPV acquisition were estimated by Poisson multiple regression.
- Publication
The Journal of infectious diseases, 2010, Vol 201, Issue 10, p1455
- ISSN
1537-6613
- Publication type
Journal Article
- DOI
10.1086/652184