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- Title
Host determinants of HIV-1 control in African Americans.
- Authors
Pelak, Kimberly; Goldstein, David B; Walley, Nicole M; Fellay, Jacques; Ge, Dongliang; Shianna, Kevin V; Gumbs, Curtis; Gao, Xiaojiang; Maia, Jessica M; Cronin, Kenneth D; Hussain, Shehnaz K; Carrington, Mary; Michael, Nelson L; Weintrob, Amy C; Infectious Disease Clinical Research Program HIV Working Group; National Institute of Allergy and Infectious Diseases Center for HIV/AIDS Vaccine Immunology (CHAVI)
- Abstract
We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P = 5.6 x 10(-10)). These analyses therefore confirm a member of the HLA-B*57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701.
- Publication
The Journal of infectious diseases, 2010, Vol 201, Issue 8, p1141
- ISSN
1537-6613
- Publication type
Journal Article
- DOI
10.1086/651382