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- Title
Low frequency nonnucleoside reverse-transcriptase inhibitor-resistant variants contribute to failure of efavirenz-containing regimens in treatment- experienced patients.
- Authors
Halvas, Elias K; Wiegand, Ann; Boltz, Valerie F; Kearney, Mary; Nissley, Dwight; Wantman, Michael; Hammer, Scott M; Palmer, Sarah; Vaida, Florin; Coffin, John M; Mellors, John W
- Abstract
The contribution of low frequency drug-resistant human immunodeficiency virus type 1 (HIV-1) variants to failure of antiretroviral therapy is not well defined in treatment-experienced patients. We sought to detect minor nonnucleoside reverse-transcriptase inhibitor (NNRTI)-resistant variants at the initiation of multidrug efavirenz-containing therapy in both NNRTI-naive and NNRTI-experienced patients and to determine their association with virologic response.
- Publication
The Journal of infectious diseases, 2010, Vol 201, Issue 5, p672
- ISSN
1537-6613
- Publication type
Journal Article
- DOI
10.1086/650542