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- Title
Transmission of HIV-1 drug-resistant variants: prevalence and effect on treatment outcome.
- Authors
Jakobsen, Martin R; Tolstrup, Martin; Søgaard, Ole S; Jørgensen, Louise B; Gorry, Paul R; Laursen, Alex; Ostergaard, Lars
- Abstract
Human immunodeficiency virus type 1 (HIV-1) drug resistance is an important threat to the overall success of antiretroviral therapy (ART). Because of the limited sensitivity of commercial assays, transmitted drug resistance (TDR) may be underestimated; thus, the effect that TDR has on treatment outcome needs to be investigated. The objective of this study was to investigate the prevalence of TDR in HIV-infected patients and to evaluate the significance of TDR with respect to treatment outcome by analyzing plasma viral RNA and peripheral blood mononuclear cell proviral DNA for the presence of drug resistance mutations.
- Publication
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2010, Vol 50, Issue 4, p566
- ISSN
1537-6591
- Publication type
Journal Article
- DOI
10.1086/650001