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- Title
Antibody responses in oral fluid after administration of prophylactic human papillomavirus vaccines.
- Authors
Rowhani-Rahbar, Ali; Carter, Joseph J; Hawes, Stephen E; Hughes, James P; Weiss, Noel S; Galloway, Denise A; Koutsky, Laura A
- Abstract
We sought to determine whether oral fluid can be used to assess serum human papillomavirus (HPV) antibody status by enrolling women who had received a prophylactic HPV-16 vaccine in a new follow-up study. After the prophylactic HPV-6/11/16/18 vaccine was licensed in the United States, we administered it to consenting participants. With serologic findings used as the reference standard, The sensitivity of oral fluid was 49.6% (95% confidence interval [CI], 42.0%-57.3%) before and 100% (95% CI, 92.0%-100%) after administration of the quadrivalent vaccine. Oral fluid may have the potential to be used for monitoring of prophylactic HPV vaccines in the future.
- Publication
The Journal of infectious diseases, 2009, Vol 200, Issue 9, p1452
- ISSN
1537-6613
- Publication type
Journal Article
- DOI
10.1086/606026