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- Title
HIV-1 infection in Zambian children impairs the development and avidity maturation of measles virus-specific immunoglobulin G after vaccination and infection.
- Authors
Nair, Nitya; Moss, William J; Scott, Susana; Mugala, Nanthalile; Ndhlovu, Zaza M; Lilo, Kareem; Ryon, Judith J; Monze, Mwaka; Quinn, Thomas C; Cousens, Simon; Cutts, Felicity; Griffin, Diane E
- Abstract
Endemic transmission of measles continues in many countries that have a high human immunodeficiency virus (HIV) burden. The effects that HIV infection has on immune responses to measles and to measles vaccine can impact measles elimination efforts. Assays to measure antibody include the enzyme immunoassay (EIA), which measures immunoglobulin G (IgG) to all measles virus (MV) proteins, and the plaque reduction neutralization (PRN) assay, which measures antibody to the hemagglutinin and correlates with protection. Antibody avidity may affect neutralizing capacity.
- Publication
The Journal of infectious diseases, 2009, Vol 200, Issue 7, p1031
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/605648