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- Title
Interleukin-10 promoter polymorphisms influence HIV-1 susceptibility and primary HIV-1 pathogenesis.
- Authors
Naicker, Dshanta D; Werner, Lise; Kormuth, Emil; Passmore, Jo-Ann; Mlisana, Koleka; Karim, Salim Abdool; Ndung'u, Thumbi; CAPRISA Acute Infection Study Team
- Abstract
Interleukin (IL)-10 directly inhibits human immunodeficiency virus type 1 (HIV-1) replication, but it may also promote viral persistence by inactivation of effector immune mechanisms. Here, we show in an African cohort that individuals with genotypes associated with high IL-10 production at 2 promoter single-nucleotide polymorphisms (-1082 and -592) were less likely to become HIV-1 infected but had significantly higher median plasma viral loads during the acute phase (<or=3 months after infection). However, as the infection progressed, the association between genotype and median viral load was reversed. Thus, IL-10 may influence HIV-1 susceptibility and pathogenesis, but effects on the latter may differ according to the infection phase.
- Publication
The Journal of infectious diseases, 2009, Vol 200, Issue 3, p448
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/600072