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- Title
Identification of nevirapine-resistant HIV-1 in the latent reservoir after single-dose nevirapine to prevent mother-to-child transmission of HIV-1.
- Authors
Wind-Rotolo, Megan; Durand, Christine; Cranmer, Lisa; Reid, Alison; Martinson, Neil; Doherty, Meg; Jilek, Benjamin L; Kagaayi, Joseph; Kizza, Allan; Pillay, Visva; Laeyendecker, Oliver; Reynolds, Steven J; Eshleman, Susan H; Lau, Bryan; Ray, Stuart C; Siliciano, Janet D; Quinn, Thomas C; Siliciano, Robert F
- Abstract
Intrapartum single-dose nevirapine decreases mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) but promotes nevirapine resistance. Although resistant viruses fade to undetectable levels in plasma, they may persist as stably integrated proviruses within the latent reservoir in resting CD4(+) T cells, potentially complicating future treatment.
- Publication
The Journal of infectious diseases, 2009, Vol 199, Issue 9, p1301
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/597759