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- Title
Low plasma level of cathelicidin antimicrobial peptide (hCAP18) predicts increased infectious disease mortality in patients undergoing hemodialysis.
- Authors
Gombart, Adrian F; Bhan, Ishir; Borregaard, Niels; Tamez, Hector; Camargo, Carlos A, Jr; Koeffler, H Phillip; Thadhani, Ravi
- Abstract
Human cathelicidin antimicrobial protein (hCAP18) is an antimicrobial and immunomodulatory peptide that has pleiotropic effects and is transcriptionally regulated by vitamin D. Because the administration of vitamin D analogues has been linked to decreased mortality among patients with end-stage renal disease, we hypothesized that low hCAP18 levels would identify those who are at increased risk of death attributable to infection while undergoing hemodialysis.
- Publication
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2009, Vol 48, Issue 4, p418
- ISSN
1537-6591
- Publication type
Journal Article
- DOI
10.1086/596314