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- Title
Mycobacterium avium paratuberculosis invades human small-intestinal goblet cells and elicits inflammation.
- Authors
Golan, L; Livneh-Kol, A; Gonen, E; Yagel, S; Rosenshine, I; Shpigel, N Y
- Abstract
Crohn disease is a chronic inflammatory bowel disease of unknown etiology. Mycobacterium avium paratuberculosis (MAP) was found in the gut of patients with Crohn disease, but causality was not established. Fully developed, germ-free human small intestine and colon were established by subcutaneous transplantation of fetal gut into SCID (severe combined immunodeficiency) mice thereafter infected by direct intraluminal inoculation of MAP. We have found that MAP actively invades the human gut epithelial goblet cells of the small intestine, inducing severe tissue damage and inflammation. These observations indicate that MAP can specifically colonize the normal human small intestine and can elicit inflammation and severe mucosal damage.
- Publication
The Journal of infectious diseases, 2009, Vol 199, Issue 3, p350
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/596033