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- Title
A newly identified bocavirus species in human stool.
- Authors
Kapoor, Amit; Slikas, Elizabeth; Simmonds, Peter; Chieochansin, Thaweesak; Naeem, Asif; Shaukat, Shahzad; Alam, Muhammad Masroor; Sharif, Salmaan; Angez, Mehar; Zaidi, Sohail; Delwart, Eric
- Abstract
Viral metagenomic analysis was used to identify a previously uncharacterized parvovirus species, "HBoV2," whose closest phylogenetic relative is the human bocavirus (HBoV). HBoV2 has a genomic organization identical to that of HBoV but has only 78%, 67%, and 80% identity, respectively, with the latter's NS1, NP1, and VP1/VP2 proteins. The study used polymerase chain reaction to detect HBoV2 sequences in 5 of 98 stool samples from Pakistani children and in 3 of 699 stool samples from Edinburgh. Nearly-full-length genome sequencing revealed the presence of 3 HBoV2 genotypes and evidence of recombination between genotypes. Further studies are necessary to identify anatomical sites of HBoV2 replication and potential associations with clinical symptoms or disease.
- Publication
The Journal of infectious diseases, 2009, Vol 199, Issue 2, p196
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/595831