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- Title
Minority quasispecies of drug-resistant HIV-1 that lead to early therapy failure in treatment-naive and -adherent patients.
- Authors
Metzner, Karin J; Giulieri, Stefano G; Knoepfel, Stefanie A; Rauch, Pia; Burgisser, Philippe; Yerly, Sabine; Günthard, Huldrych F; Cavassini, Matthias
- Abstract
Early virological failure of antiretroviral therapy associated with the selection of drug-resistant human immunodeficiency virus type 1 in treatment-naive patients is very critical, because virological failure significantly increases the risk of subsequent failures. Therefore, we evaluated the possible role of minority quasispecies of drug-resistant human immunodeficiency virus type 1, which are undetectable at baseline by population sequencing, with regard to early virological failure.
- Publication
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2009, Vol 48, Issue 2, p239
- ISSN
1537-6591
- Publication type
Journal Article
- DOI
10.1086/595703