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- Title
New generation of inactivated poliovirus vaccines for universal immunization after eradication of poliomyelitis.
- Authors
Chumakov, Konstantin; Ehrenfeld, Ellie
- Abstract
Twenty years of global polio eradication efforts may soon eliminate the transmission of wild-type poliovirus. However, new information that has been learned about poliovirus, as well as the political realities of a modern world, demand that universal immunity against poliomyelitis be maintained, even after wild-type poliovirus is eradicated. Although 2 excellent vaccines have proven to be highly effective in the past, neither the live-attenuated vaccine nor the currently used inactivated vaccine are optimal for use in the posteradication era. Therefore, concerted efforts are urgently needed to develop a new generation of vaccine that is risk-free and affordable and can be produced on a global scale. Here, we discuss the desired properties of a vaccine and methods to create a new polio vaccine.
- Publication
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2008, Vol 47, Issue 12, p1587
- ISSN
1537-6591
- Publication type
Journal Article
- DOI
10.1086/593310